Diagnostic Accuracy of Positron Emission Tomography-Computed Tomography (PET-CTScan) In Detecting Bone Marrow Involvement in Patients with Diffuse Large B cell Lymphoma


  • Mohammad Usman Shaikh Department of Pathology and Laboratory Medicine/Oncology,Aga Khan University Karachi, Pakistan. Karachi
  • Danish Shakeel
  • Muhammad Hassan
  • Nayab Afzal
  • Natasha Ali
  • Salman Adil


NHL, PET- CT scan, bone marrow biopsy, DLBCL


Objective: To evaluate the diagnostic accuracy of Positron Emission Tomography combined with CT scan (PET-CT Scan) in detecting bone marrow involvement in patients with Diffuse Large B-cell lymphoma keeping bone marrow biopsy as gold standard.

Methodology: Descriptive cross sectional study was conducted at Section of Clinical Hematology, Department of Oncology at Aga Khan University, Karachi, from November 2017 to May 2018.A total of 112 patients who were diagnosed as Diffuse Large B Cell Lymphoma upon histopathological examination of involved lymph node were included in the study. As a part of staging work up all patients underwent PET-CT scan and bone marrow biopsy procedure. Diagnostic accuracy of PET-CT scan for detection of bone marrow involvement was evaluated keeping bone marrow biopsy as gold standard.

 Results: Of 112 patients, there were 71(63%) males and 41(37%) females. The mean age was 45.09±17.36years. Mean duration of diagnosis was 17.19±6.02 days. Bone marrow involvement through biopsy was seen in 40(35.7%) cases. Bone marrow involvement through PET- CT scan was found in 47(41.9%) cases. The PET- CT Scan in comparison with bone marrow biopsy for detecting bone marrow involvement in patients with DLBCL had a sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of 95%, 87.7%, 80.85%, 96.92% and 90.18% respectively.

Conclusion: PET-CT scan can accurately detect bone marrow involvement in patients with DLBCL so it can be used in most patients instead of invasive bone marrow biopsy procedure for staging of DLBCL patients.





Original Articles