Association of Contrast-Induced Nephropathy with Adverse In-Hospital Outcomes in Patients Undergoing Primary Angioplasty for Acute Myocardial Infarction

Abstract

Objective: To assess the association of contrast-induced nephropathy (CIN) and adverse in-hospital outcomes in patients undergoing primary angioplasty for acute myocardial infarction (AMI).

Methodology: A prospective cohort study was done in National Institute of Cardiovascular Disease (NICVD), Karachi from January 2019 to January 2020. After taking informed written consent clinical examination was done and blood investigations were done at the time of admission and repeated on 3rd day for in hospital outcome i-e atrial fibrillation, cardiogenic shock, and acute pulmonary edema and CIN.

Results: Total of 249 patients with AMI undergoing PPCI were included. Out of all 99(39.7%) were females and 150(60.3%) were males with mean age of 54.82+7.888 years. The in-Hospital outcome atrial fibrillation, cardiogenic shock & acute pulmonary edema in exposed group were seen in 27(10.8%), 37(14.9%) & 29(11.6%) respectively, while in non-exposed group these were noted in 8 (3.2%), 9(3.6%) & 10 (4%) respectively.

Conclusion: The patients who developed CIN after primary angioplasty for AMI observed with higher adverse in-hospital outcomes in contrast to those who did not developed renal impairment, indicating that the occurrence of CIN worsens the clinical progression during hospitalization and rises the complications risk.