Role of Zinc Supplementation in Reducing Relapses in Steroid Sensitive Nephrotic Syndrome

Authors

  • Fatima Hashmi Children Hospital (PIMS)
  • Shahzadi Sumbal Ghazi Holy Family Hospital/ Rawalpindi Medical University
  • Hassan Mumtaz KRL Hospital
  • Maryum Amjad Holy Family Hospital/ Rawalpindi Medical University
  • Nahdia Zaman Holy Family Hospital/ Rawalpindi Medical University
  • Shahzaib Ahmad King Edward Medical University, Lahore

DOI:

https://doi.org/10.48036/apims.v17i3.408

Keywords:

Relapse Steroid-sensitive, nephrotic syndrome, Zinc., Pathogenesis

Abstract

Objective: To evaluate and compare the effectiveness of zinc and B-Complex supplementation to prevent the recurrence of nephrotic syndrome in the cases priory responsive to corticosteroid therapy.

Methodology It is a randomized controlled trial conducted at OPD Pediatric medicine, Shaheed Zulfiqar Ali Bhutto University, PIMS Children Hospital Islamabad from October 3, 2016 to April 2, 2017. 192 patients (96 in each group) were included in the study after obtaining informed consent from parents or guardians taken before determining the population. Patients were randomly assigned to two groups (Group 1: Zinc and Group 2: B-Complex) to receive oral zinc sulphate (10 mg / day) or B-Complex using a random number table. The patients were followed up after 4 months. All data were collected by the researchers themselves in a structured form.

Results: The age of 192 participants of the trial averaged 6.38±3.42 years of age ranging from 1-12 years. There were 88 (45.8%) men and 104 (54.2%) women cases. In group 1, there were 22 (22.9%) and in group 2, there were 47 (49%) cases that had been pardoned. The recurrence of nephrotic syndrome was significantly higher in group 1 than group 2 (p = <0.001).

Conclusion: The findings of this study suggest that Zinc supplementation is more preferrable to B-Complex supplementation as the rate of continuous remission was higher in the zinc group, so in the future may be added to the treatment regimen to treat steroid-sensitive nephrotic syndrome.

Author Biographies

Fatima Hashmi, Children Hospital (PIMS)

Post Graduate Trainee : Neonatology

Shahzadi Sumbal Ghazi, Holy Family Hospital/ Rawalpindi Medical University

Senior Registrar Paediatrics

Maryum Amjad, Holy Family Hospital/ Rawalpindi Medical University

Senior Registrar Paediatrics

Nahdia Zaman, Holy Family Hospital/ Rawalpindi Medical University

Senior Registrar Paediatrics

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Published

2021-11-15

Issue

Section

Original Articles