The Physiological Association Between Mean Platelet Volume and Diabetes Mellitus Type 2: Correlation Between HbA1c Score and MPV Index

Abstract

Objective: To evaluate difference in mean platelet volume between non-diabetics and diabetics individual and to find the relationship between Hba1c level and MPV among type 2 diabetic individuals.

Methodology:  This was a retrospective study conducted from December 2022 to November 2023 in Muhammad Medical College and Hospital with prior approval from ethical committee via letter No: Physiol dated 10-03-20. By random sampling 370 participants were selected in which 214 were diabetics and 156 were non-diabetics. Their blood pressure, BMI, Hba1c level, fasting and post prandial glucose level was measured. For evaluation of complete blood picture and MPV an automatic (Beckman coulter) machine was used. Statistical analysis was done by Graph Pad Prism 9.

Results: it was noted that both male and female show significant association between raised MPV and increased serum glycemic level (P value less than 0.05). In male MPV increased in 21.89% patients (x2 =33.96, df=3 and P value= 0.0001). In female MPV increased in 17.29% patients (Odd ratio3.07 and P value= 0.0006).

Conclusion: Mean platelet volume in diabetics was found to be higher as compared to non-diabetic subjects. In diabetic patients with Hba1c less than 6.5% had less raised MPV as compare to diabetics with Hba1c level greater than 6.5%.