Comparing the Effectiveness of Tramadol versus Paroxetine in the Treatment of Premature Ejaculation

Authors

  • Shoukat Ali Mughal Assistant Professor,  Liaquat University of Medical and Health Sciences Jamshoro Pakistan.      
  • Syed Azhar Hussain Senior Registrar, Liaquat University of Medical and Health sciences Jamshoro/ Hyderabad, Pakistan 
  • Zakir Hussain Rajpar Associate Professor,  Liaquat University of Medical and Health Sciences Jamshoro. Hyderabad, Pakistan 
  • Kashif Uddin Qayoom Soomro Assistant Professor, Liaquat University of Medical and Health Sciences Jamshoro,                  Hyderabad - Pakistan
  • Aijaz Shaikh   Consultant Urologist, Liaquit University hospital Hyderabad Pakistan
  • Afhan Qayoom Shaikh Consultant Urologist, Liaquat university hospital Hyderabad Hyderabad Pakistan 

DOI:

https://doi.org/10.48036/apims.v20i3.1092

Keywords:

Premature ejaculation, Proxetine

Abstract

Objective: To conduct a comparative analysis of the effectiveness of tramadol versus paroxetine in managing premature ejaculation (PE).

Methodology: This study employs a randomized, double-blind, parallel-group design conducted at the Urology department of Liaquat University of Medical and Health Sciences Jamshoro, Hyderabad, Pakistan. Participants are adult males aged 18–65 years who report persistent PE were included in the study. Premature ejaculation occurs in men when semen leave the body (ejaculate) sooner or just before penetration. Participants meeting the diagnostic criteria for PE are assigned randomly to either the tramadol group or the paroxetine group. Participants in the tramadol group receive oral tramadol hydrochloride at a dose of 50 mg, taken 1–2 hours before anticipated sexual activity. Participants in the paroxetine group receive oral paroxetine hydrochloride (20mg daily), taken continuously for 8 weeks. The primary outcome measure is the change or delay in intravaginal ejaculatory latency time (IELT).

Results: The mean baseline IELT and after treatment IELT in tramadol group was statistically significant (p<0.001), 47.83±5.68 seconds and 141.54±4.04 seconds, respectively. Similarly, the mean baseline IELT and after treatment IELT in the paroxetine group was statistically significant (p<0.001), 47.03±5.48 seconds and 98.67±4.68 seconds, respectively.

Conclusion: Tramadol is an effective alternative to paroxetine in treating premature ejaculation, with studies showing it significantly delays ejaculation similar to paroxetine, providing patients more options for managing lifelong PE.

Author Biography

Shoukat Ali Mughal, Assistant Professor,  Liaquat University of Medical and Health Sciences Jamshoro Pakistan.      

    

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Published

2024-06-11

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Original Articles