"Exploring the superior efficacy of hyaluronic acid and platelet-rich plasma co-administration over hyaluronic acid alone in pain reduction and functional status improvement of knee osteoarthritis patients."

Authors

  • Waqas Ali CMH Kharian Maedical College
  • Muhammad Zahid Siddiq Assistant Professor of Orthopaedics Nawaz Sharif Medical College, Gujrat.
  • Warda Hussain Nawaz Sharif Medical College, Gujrat
  • Zeeshan Ali Post-Graduate Resident Orthopaedic Surgery Nawaz Sharif Medical College, Gujrat
  • Muhammad Akram Associate Professor of Orthopaedics Mayo Hospital/King Edward Medical University Lahore
  • Abdul Hannan Assistant Professor of Orthopaedics University College of Medicine & Dentistry Lahore

Abstract

Objective: This study's main goal was to ascertain if injecting HA concurrently with PRP would increase therapy effectiveness in comparison to PRP alone in the management of knee OA with a long-term follow up of 12 months.

Methodology: 100 patients were included in this prospective comparative study having history of knee pain or swelling not improving with medications and physiotherapy for at least 4 months and presence of degenerative changes in the joint (Kellgren – Lawrence scale grade 0 to III) in the plain radiographs or magnetic resonance images (MRI).  Hyaluronic acid (HA) alone was injected in knee joints of 50 patients (group 1) while other fifty patients were treated with Platelet Rich Plasma plus Hyaluronic acid (PRP+HA) intra-articular knee injection (group 2). 

Results: Basal, 2 month, 6 month and 12 month assessment after intra articular injection of HA and PRP+HA was compared. both groups demonstrated very remarkable improvement when compared to the basal assessment and same results were observed at 12- month follow up. VAS and WOMAC scores were calculated and compared in both groups. There was significant improvement in group 2 patients receiving intra articular injection of PRP and HA when compared with group 1 receiving HA alone (p< 0.05). P value at 2, 6 and 12 months in WOMAC score 0.001*,0.001*, 0.000* respectively.

Conclusions. Combination of PRP+HA is more effective as compared to HA alone for knee osteoarthritis.

Key words:  Platelet Rich Plasma, knee osteoarthritis, Hyaluronic acid, WOMAC, VAS

Author Biographies

Muhammad Zahid Siddiq, Assistant Professor of Orthopaedics Nawaz Sharif Medical College, Gujrat.

 

 

Zeeshan Ali, Post-Graduate Resident Orthopaedic Surgery Nawaz Sharif Medical College, Gujrat

 

 

 

 

Muhammad Akram, Associate Professor of Orthopaedics Mayo Hospital/King Edward Medical University Lahore

 

 

 

Published

2024-06-11

Issue

Section

Original Articles