Efficacy of resomal versus low osmolar ORS in severe acute malnutrition children with diarrhea age 6 months to 59 months

Abstract

Objective: To compare the efficacy of Resomal versus low Osmolar ORS in severe acute malnutrition in children with diarrhea age 6 months To 59 months.
Methodology: This Randomized Control Trial was carried out at Nutrition stabilization Centre pediatrics Department, Liaquat university hospital, Hyderabad, with duration of one year from 1^st April-2016- to 31^st March-2017. All the children having severe acute Malnutrition were included. After admission, severity of diarrhea was assessed on clinical basis. After informed consent, patients of Severe Acute Malnutrition were divided into two groups i.e Group-A and Group-B on randomized selection. Group A was given Resomal and Group–B was given low Osmolar ORS. Electrolytes were sent on admission then again after 12 hours of giving rehydration solution, response of diarrhea was assessed on the basis of Laboratory investigations and clinical assessment.
Results:  Mean age of the children was 20.83 months and standard deviation was 3.52 months. Female children were in the majority 172 as compared to males 152 out of 324 cases. No significant difference was found in Z-score of both groups, P-value 0.07. Acute diarrhea was the most common in both groups, Diarrhea frequency-1 was found significantly more in both groups, having p-value 0.001, while frequency 2 and 3 were found without significant difference in both groups.  Statistically there was a significant difference in pre rehydration electrolytes in both groups, having p-value 0.001.  After rehydration no significant difference was found in electrolytes in both groups.
Conclusion: It was concluded that resomal and low osmolar ORS were similarly efficacious in the rehydration of severely malnourished children with diarrhea and dehydration after rehydration.