Serum Cobalamin Levels and Red Blood Cell Morphology Among Celiac Disease Patients

Abstract

Objective: To evaluate serum cobalamin level and red blood cell morphology among Celiac disease patients.

Methodology: This Case control study was conducted at Department of Physiology, Medicine and Gastroenterology Unit, Isra University Hospital Hyderabad from March 2017 to October 2017. All the participants were divided equally in two groups. Group I. Controls- normal healthy subjects (n=45).  Group II. Cases diagnosed cases of Celiac disease (n=45). Red blood cell morphology was assessed under light microscopy at postgraduate Laboratory. Serum cobalamin was determined by competitive EIA technique. All the data was recorded in the proforma.

Results: Total 90 cases were studied out of them 45 were patients of celiac disease and 45 were normal. Mean age of controls cases was 47.53±8.13 years and celiac disease patient’s was 46.84±7.69 years. Male were found in majority of both group’s cases and controls as 82.2% and 73.3% respectively. Mean of serum cobalamin level was significantly lower among patients as 201.36±74.77 pg/mL in contrast to controls as 247.06±60.34 pg/mL p= 0.002. Hemoglobin and hematocrit levels were also low in cases compared to controls. RBC indices showed macrocytic, microcytic, hyperchromic and megaloblastic changes.

Conclusion: Serum cobalamin was decreased among celiac disease patients and disturbed RBC indices as macrocytic, microcytic, hyperchromic and megaloblastic were common in the Celiac disease patients.