Confederacy of ABO Alleles with Ischemic Heart Disease: An Angiographic Study
Objective: To establish whether the ABO alleles are in confederacy with Ischemic Heart Disease (IHD) in Pakistani Population
Study Design: Analytic comparative study
Place and Duration: Punjab Institute of Cardiology Lahore, from September 2015 to September 2016
Methodology: About 734 IHD suspects and 500 controls were selected via non-probability purposive sampling techniques. Out of 734 suspects of IHD, 599 (81%) were diagnosed as confirmed IHD patients by interventional coronary. Control group were selected from adult healthy blood donors with no symptoms of IHD and normal ECG. All subjects were processed for ABO blood grouping, Baseline characteristics and cardio-vascular risk factors were assessed by a cardiologist. Chi-square test was used as a test of significance; p-value of <0.05 was considered statistically significant. Win Pepi software was used for statistical analysis of data.
Results: Mean age of cases and control was 48±12.34 years and 47.3±2.38 years respectively. Both in cases and controls, number of males were more as compared to females. Blood group A and AB was significantly more in cases as compared to control. In control group blood group B and O was significantly more frequent as compared to cases. Among cases most common risk factrs were smoking (77.1%), ghee abuser (75%), hyperlipidemia (73.1%) and hypertension (71.1%). Majority of controls (59.2%) gave history of performing exercise (Table I). All the risk factors had a significant association with types of blood group.
Conclusion: Blood groups are significantly different between cases and controls. Risk factors have significant association with blood groups.