INFILTRATION OF ROUND BLUE CELL TUMORS IN BONE MARROW
Objective: To identify the different types of Round Blue cell tumors on bone marrow biopsy and their pattern of marrow infiltration.
Methodology: This Cross-sectional descriptive study was conducted at the Department of Hematology, Armed Forces Institute of Pathology (AFIP), Rawalpindi from July 2021 to December 2021. A total of 60 diagnosed cases of round blue cell tumors were included in this study. Patients with acute lymphoblastic leukemia (ALL) and patients of round blue cell tumors on treatment were not included in this study.Bone marrow aspiration and biopsy were performed. Peripheral film results, clinical observations, and patterns of marrow infiltration of Round Blue cell malignancies were reported on Statistical Package for the Social Sciences (SPSS) version 23 was used for data analysis.
Results:Our investigation revealed a male to female ratio of 2:1, with 40 (66.6%) males and 20 (33.3%) females. The overall average age was 5.695.0years. Ewing sarcoma and Rhabdomyosarcoma patients did not exhibit infiltration, however three instances of retinal blastoma (9.37%) and two cases of Neuroblastoma (10.52%) did. IHC results for Synaptophysin and Chromgranin indicated positive results for Retinoblastoma and Neuroblastoma, while S100 results were positive for Neuroblastoma infiltration and negative for Retinoblastoma.Both Retinoblastoma and Neuroblastoma showed diffuse, focal and interstitial pattern of infiltration on trephine biopsy.
Conclusion:Small round blue cell tumors were noted in bone marrow infiltration 5 (8.33%) cases. Early detection of malignant cancers necessitates appropriate medical care and in more severe cases need of neoadjuvant chemotherapy.
Key words: Small round blue cell tumors, Neuroblastoma, Retinoblastoma.
Copyright (c) 2023 Zahra Tasleem, Dr. Hamid Saeed Malik, Dr. Saima Bashir, Dr Hassan Shaukat, Dr. Halima Babar, Dr. Kehkashan Hassan
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