Outcome of non-invasive ventilation in severe COVID patients, A prospective cohort study


  • Roshaan Tahir medicine


Background:COVID-19 patients who experience severe SARS-CoV-2 infection develop pneumonia, requiring hospital admissions, oxygen and even ventilator support. Acute respiratory distress can lead to respiratory failure, hypercoagulability, septic shock & multi-organ involvement, all of which can increase mortality in severe cases.

Objective:To determine the Outcome of non-invasive ventilation in severe COVID patients.

Study Design: Prospective Cohort study

Methodology:Eighty seven patients of age 45 to 75 years, admitted in PEMH due to severe SARS-COV2 infection were included in this study. These patients were COVID PCR positive as well as had signs ,symptoms and radiological evidence consistent with COVID19 pneumonia. These patients were put on NIV trial. The primary outcomes were intubation success and failure, as well as the mortality rate. SPSS 2021 was used to enter and analyze the data.

Results:The mean age was 62.89 ±7.55 years. There were 65(74.7%) males and 22(25.3%) females. NIV was successful in 33patients (37.9%) while in 54(62.1%) patients required endotracheal intubation and 24 (27.8%)patients died during follow-up. The mean duration of NIV support was observed as 6.2 ± 3.9 days.

Conclusion: NIV can prevent intubation in nearly half of the patients, according to our findings.

Key words: Outcome, non-invasive ventilation, severe COVID-19, SARS-CoV-2, respiratory rate, intubation





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