Diabetes and Inflammation: Association between C-reactive protein and diabetic Nephropathy

Authors

  • Hassan Salim Foundation Hospital Rawalpindi
  • Shahida Perveen Foundation University Medical College, Islamabad,
  • Mahwish Niaz Shifa college of medicine, Shifa tamer-e- millat university,Islamabad
  • Omar Ahsan Foundation University Medical College, Islamabad
  • Umm-e- Farwa QIMS ,Quetta
  • Rehana Ramzan Foundation University Medical College, Islamabad
  • Hassan Mumtaz Maroof International Hospital, Health Services Academy http://orcid.org/0000-0003-2881-2556

Keywords:

C-Reactive Protein, Diabetes mellitus;, Proteinuria, Nephropathy

Abstract

Objective: To determine the frequency of elevated C-reactive protein in type 2 diabetics and to compare the levels of C-reactive protein between people with diabetes and non-diabetics Nephropathy

Study Design: Cross-Sectional Comparative study

Settings: Diabetic and Medical OPD of Fauji Foundation Hospital, Rawalpindi

Duration: Jan 2019 to July 2019

MATERIAL AND METHODS: A total of 150 patients, who met the inclusion criteria, were studied. Blood samples were collected for blood sugar random, fasting, renal function test, WBC count, and C-reactive protein. Urine samples were collected for the measurement of 24-hour urinary proteins. The presence or absence of proteinuria was used to categorize patients into two groups. Group A included 58 patients with type 2 diabetes without Nephropathy, and Group B included 92 patients with type 2 diabetes with Nephropathy (proteinuria > 30 mg/dl in 24 hrs).

RESULTS: Mean age in our study was 49.41+7.66. Ninety-two patients (61.3%) presented with diabetic Nephropathy. CRP levels (> 8200 ng/ml) were raised in 50 (54.3%) patients of group B and 19 (32.8%) patients of group A. The difference was statistically significant (p-value 0.010).

CONCLUSION: This study showed a higher prevalence of raised CRP in type 2 diabetics with Nephropathy. This reinforces the idea that low-grade inflammation has an essential role in the inception and evolution of the diabetic renal disease.

Author Biographies

Hassan Salim, Foundation Hospital Rawalpindi

Senior Registrar, Department of Medicine

Shahida Perveen, Foundation University Medical College, Islamabad,

Assistant professor,

Department of Medicine

Mahwish Niaz, Shifa college of medicine, Shifa tamer-e- millat university,Islamabad

Assistant Professor,

Department of Pathology

 

Omar Ahsan, Foundation University Medical College, Islamabad

 

Associate Professor,

Department of Medicine, 

Umm-e- Farwa, QIMS ,Quetta

Demonstrator

Department of Pathology

 

Rehana Ramzan, Foundation University Medical College, Islamabad

 

Demonstrator

Department of Pathology

 

Hassan Mumtaz, Maroof International Hospital, Health Services Academy

Clinical Research Associate, Maroof International Hospital

Public Health Scholar, Health Services Academy

 

 

Published

2022-09-11

Issue

Section

Original Articles