P53 Over Expression in Bladder Carcinoma

Authors

  • Sabeen Afshan Fatima jinnah chest and general hospital Quetta
  • Laila Zaib Loralai Medical College
  • Sumera Sharif Christian hospital taxilla
  • Javeria Faridi Sheikh khalifa bin Zayed hospital Quetta
  • Farzana Habib Chughtai Stat Lab, Mirpur AJK ( Al-Seha Care Hospital )
  • Aisha Akbar Associate Professor Pathology Rawal institute of health sciences.Islamabad http://orcid.org/0000-0003-2881-2556

Keywords:

urothelial carcinoma, Immunohistochemistry, P53 overexpression, Histopathology, Urology

Abstract

 

Objective: The goal of this study was to find out how common p53 overexpression is in bladder urothelial carcinoma.

Material & Methods: This Descriptive, Cross-Sectional Study has been done during April 10th to October 9th, 2018 at the KRL Hospital Islamabad. A total of 74 patients with biopsy-proven urinary bladder carcinoma, ranging in age from 15 to 70 years old and regardless of gender, were included in the study. Patients undergoing radiotherapy, immunotherapy, or who had previously received an immunohistochemistry report were excluded. Following that, the immunohistochemical processing was completed, and the results for p53 expression (positive/negative) were interpreted by the consultant pathologist.

Results: The participants in this study ranged in age from 15 to 70 years old, with a mean age of 47.39 10.26 years. The male to female ratio was 1.6:1 among these 74 patients, with 45 (60.81 percent) being male and 29 (39.19 percent) being female. Overexpression of p53 was found in 31 (41.89 percent) of bladder urothelial carcinoma cases.

Conclusion: This study concluded that the frequency of p53 overexpression in bladder urothelial carcinoma is very high.

Author Biographies

Sabeen Afshan, Fatima jinnah chest and general hospital Quetta

Lady Medical Officer

Laila Zaib, Loralai Medical College

Demonstrator, Pathology department

Sumera Sharif, Christian hospital taxilla

Pathalogist 

Javeria Faridi, Sheikh khalifa bin Zayed hospital Quetta

Assistant professor. Pathology department

Farzana Habib, Chughtai Stat Lab, Mirpur AJK ( Al-Seha Care Hospital )

Consultant Pathologist

Published

2022-09-11

Issue

Section

Original Articles