Immuno Histochemical Expression of CD10 OR CA19.9 in Urinary Bladder Transitional Cell Carcinoma

Expression of CD10 OR CA19.9

Authors

  • Rehana Ramzan Fauji Foundation Hospital
  • Umm-e- Farwa Fauji Foundation Hospital
  • Mahwish Niaz Shifa College of Medicine, Shifa Tameer-e-Milat University
  • Kashif Bangash KRL Hospital
  • Zainab Taj AFIP
  • Hassan Salim Fauji Foundation Hospital Rawalpindi

Keywords:

CA19.9, Immunohistochemistry, CD10, Urothelial Carcinoma

Abstract

Objectives: To determine the frequency of immune histochemical expression of CD10 and CA19.9 in patients of papillary urothelial carcinoma of the bladder following the WHO 2004 grading of the tumor.

Methodology: This Descriptive, Cross-sectional survey has been done in during 21st October 2017 to 20th October 2018. A total of 75 patients with a diagnosis of papillary urothelial carcinomas of urinary bladder on histopathology, using TURBT, from 40 to 80 years of age, irrespective of gender were included.

Results: Out of these 75 patients, 39 (52.0%) were male and 36 (48.0%) were female with a male to female ratio of 1.1:1. The frequency of positive expression of CD10 and CA19.9 on immunohistochemistry was found in 41 (54.67%) & 39 (52.0%) cases. It was seen that positive CD10 expression was found in 12 (31.58%) low-grade tumors and in 24 (63.16%) high-grade tumors. Positive CA19.9 expression was found in 29 (78.38%) low-grade tumors and 15 (40.54%) high-grade tumors.

Conclusion:  The study concluded that there was an increased CD10 expression in high-grade urothelial carcinomas while low-grade urothelial carcinomas showed an increased expression of CA19.9.

 

Author Biographies

Rehana Ramzan, Fauji Foundation Hospital

Histopathologist

Umm-e- Farwa, Fauji Foundation Hospital

Histopathologist

Kashif Bangash, KRL Hospital

Assistant Professor of Urology

Zainab Taj, AFIP

Histopathologist

Hassan Salim, Fauji Foundation Hospital Rawalpindi

Classified Medical Specialist

Published

2022-06-22

Issue

Section

Original Articles