The Role of Serum C - reactive protein, White Blood Cell Count and Neutrophils Percentage in the Diagnosis of Childhood Acute Appendicitis
Objective: To find out the role of CRP, white cell count and granulocytosis in accurately diagnosing Acute Appendicitis. Sensitivity, specificity, positive predictive value negative predictive values of these tests was calculated. Place and Duration of the study: This cross sectional study was conducted in immunology department of the children’s hospital and University of Child Health Sciences, Lahore over a time period of six months from July 2019 to December 2019. Material and Method: Total 91 suspected patients of Acute Appendicitis were including. The blood samples were taking from the patients and sent to the lab immediately for the estimation of serum CRP, WBC count and Neutrophil Percentage. The sensitivity, specificity, positive predictive value and accuracy were calculated for each test and then combine sensitivity, specificity, positive predictive value and accuracy calculated. Result: There were 55 (60.4%) males and 36(39.6%) females under the age of 2-16 years. Out of 91 patients, 71 patients had acute appendicitis and 20patients had normal Appendix. Out of 71 there were 46 Patients had Acute Appendicitis, 22 patients had perforated appendix and 3 patients who had gangrenous appendix. The sensitivity, specificity, accuracy, positive predictive value and negative predictive values of these 3 test 93.87%, 83.63%, 88.5%, 92% and 63.63% respectively. Conclusion: The combination of clinical signs and symptoms along with measurements of Serum CRP, WBC count and neutrophils percentage can enhance the pre-surgical decision and save the children both ways that is from negative surgery and complication of appendicitis if un-operated.
Key Words: CRP, WBC, Nu%, Appendix, Accuracy, Sensitivity, Positive Predictive Value.
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