Effect of Dilution of Propofol on Pain at Site of Injection: Comparison Between 1% vs. 0.33% Formulation


  • Khawaja Kamal Nasir PIMS
  • Rashid Hussain
  • Arshad A Shahani Assistant Professor, Department of Anaesthesia, Holy Family Hospital, Rawalpindi
  • S.H. Waqar Professor of Surgery, PIMS, Islamabad
  • Zunaira Tahir




Intravenous anaesthesia, Pain at the site of injection


Objective: To study the effect of propofol dilution on pain at injection site with formulations of 1% and 0.33%.

Methodology: A randomized controlled trial was conducted for 24 months at the Department of Anaesthesia and Critical Care, Pakistan Institute of Medical Sciences Islamabad. A total of 100 patients were included in the study. Patients were divided into two equal groups: group C received 1% propofol while patients of group D received 0.33% formulation diluted with distilled water. Patients received propofol at the start of anesthesia before any premedication. A 5ml volume was injected over a period of 5s in an 18G cannula over dorsum of hands. Behaviourial pain scale was used and descriptive data analysis was done.

Results: Then mean age of patients was 37.36±14.77 with 46 males and 56 females. Pain at the injection site was experienced in 20 (40%) patients of group C whereas 16 (32%) patients experienced pain in group D. There was no association of pain with a strength of propofol solution (p value 0.405).
Conclusion: Strength of propofol solution has no association of pain at the injection site and dilution has no better effect in terms of pain score





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