Prevalence of Helicobacter Pylori in Type II Diabetes Mellitus
Objective: To determine the prevalence of Helicobacter pylori infection in type 2 diabetes and non-diabetes patients.
Methodology: This case control study was conducted in Microbiology Department, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre Karachi with collaboration of diabetic clinic of medical and gastroenterology OPD, from June 2019 to November 2019. Known cases of type 2 diabetes mellitus, irrespective of gender, above 30 years of age and in equal number non-diabetic patients with history of epigastric burning, epigastric pain, belching, bloating, nausea, vomiting for >1 month were included. Three ml venous blood was taken from antecubital vein after overnight fasting of 8-12 hours for blood sugar fasting. Patients underwent H. pylori Antigen Rapid Test Cassette (Stool). All the data was recorded on self-made proforma. Data was analyzed by using SPSS version 20.
Results: In diabetic group most of the cases 35.2% were more than 60 years old and in non-diabetic group majority of the cases 44.8% were <50 years. Females were most common in both diabetes non-diabetes groups. Total of 83(79%) of diabetic group and 54 (51.4%) of non-diabetic were labeled as positive for H. pylori infection (p=0.001). Diabetic patients >50 years of age, were significantly associated with h-pylori infection, (p-0.001), while there was no significant impact found of gender on H-pylori infection (p-0.330).
Conclusion: H. pylori infection in diabetic patients was higher as compared to non-diabetes. Effectiveness of stool antigen method is the best diagnostic tool for the detection of H. pylori infection in diabetic subjects.
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