Reepithelialization in noise exposed skin wound

Abstract

Objective: To observe the effect of noise on reepithelialization in rat skin wound.

Methodology: A Quasi experimental study was conducted in Anatomy Department of Al-Nafees Medical College Isra University Islamabad & National Institute of Health (NIH) Islamabad from June 2015 to February 2016. Thirty male sprague Dawley rats were divided into control and experimental groups by convenient sampling. Each main group comprised of 15 rats. An incision of 2 cm was made on dorsal region of all rats. Control sub groups were left to heal with routine background noise exposure, while experimental sub groups underwent a 4 hour/day intermittent noise exposure of 85-95 db, five days a week for two consecutive weeks. Five rats from each group were sacrificed on day 3, 7 and 14. Wounds were excised, fixed and processed for haematoxilin and eosin stain to see the thickness of epithelium in rat skin wounds

Results: Process of reepithelialization was not as significant in noise induced group as noticed in control group (routine noise exposed)

Conclusion: Noise adversely affects the skin wound healing by interfering with epidermal regeneration