Comparison of the Efficacy of Combined Therapy with Oral Tamsulosin Plus Oral Diclofenac and Tamsulosin Alone in Time & Rate of Expulsion of Distal Ureteric Stones

Authors

  • Sarah Saleem Senior Lecturer, Islamabad medical and dental college
  • Sarwat Jahan North West School of Medicine, Peshawar
  • Aamna Khokhar Associate Professor, Islamabad Medical and Dental College, Islamabad
  • Mehreen Mirza Senior Lecturer, Islamabad Medical and Dental College, Islamabad
  • Salman Zahir Northwest general hospital and research center

Keywords:

Urolithiasis, medical expulsive therapy (MET), tamsulosin, diclofenac Sodium.

Abstract

Objectives: To compare the effectiveness of combined therapy with Tamsulosin and Diclofenac sodium and Tamsulosin alone in the rate and time of expulsion of distal ureteric stones of size ranging from 5-<9mm.

Methodology: This randomized clinical trial study was conducted at Benazir Bhutto Hospital Rawalpindi and Institute of Kidney Diseases-Hayatabad Medical Complex Peshawar from December 2019 to December 2020. All male and female patients presenting to the urology OPD diagnosed with unilateral distal ureteric stones on X-ray KUB were recruited using systematic random sampling and divided into two groups: Group A (study group) and Group B (control group). Patients with odd numbers were assigned to Group A, while those with even numbers were assigned to Group B. Group A received Tab. Tamsulosin 0.4mg OD and Tab. Diclofenac sodium 75mg BD for 21 days. Group B received Tab. Tamsulosin 0.4 mg OD for 21 days and acetaminophen 500mg SOS.

Results: The clinical trial revealed that in the group of patients receiving Tamsulosin and diclofenac, the rate of expulsion of distal ureteric stones was improved with a statistically significant difference. Time of expulsion of stones in two groups wasn’t statistically different.

Conclusions: Tamsulosin and Diclofenac sodium given together have added effect /benefit as compared to Tamsulosin alone in the rate and time of expulsion of distal ureteric stones.

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Published

2024-01-09

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Original Articles