Prognostic and predictive implications of Sokal scoring system in newly diagnosed Chronic Myeloid Leukemia patients

Authors

  • Halima Babar Doctor

Abstract

ABSTRACT

OBJECTIVE: To assess the predictive utility of the Sokal scoring system for determining disease prognosis in newly diagnosed patients of chronic myeloid leukaemia (CML).

STUDY DESIGN: Cross-sectional study.

PLACE AND DURATION OF STUDY: Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from Sep 2021 to Sep 2022.

METHODOLOGY: This study employed all newly diagnosed Philadelphia-positive chronic myeloid leukemia (CML) patients. Patients having CML in the accelerated and blast phases, as well as those with atypical CML, were excluded from the study. The qualitative variable of interest included gender, while the quantitative variables of interest included platelet count, spleen size, age and percentage of myeloblasts in the peripheral blood. These variables were documented on preformed data and the prognostic class of every patient was recorded. Follow-up was assessed after 03 months for those patients who had received the same tyrosine kinase therapy (TKI) to avoid any bias.

RESULTS: A total of 62 patients were employed in this study. The mean patient age was 46 5 years. Based on the Sokal scoring system, 20 of 62 patients (32%) were classified as a low-risk category, 34 patients (54.8%) as an intermediate-risk category and 8 (12.9%) as a high-risk category.

CONCLUSION: Owing to the cost-effectiveness of the traditional prognostic scoring systems, their routine implication is beneficial in the stratification of CML patients into different risk groups.

KEYWORDS: Chronic Myeloid Leukemia (CML), Sokal scoring system, Philadelphia.

Published

2024-01-09

Issue

Section

Original Articles