Spinal Anesthesia in General Surgical Patients: Comparison of 0.75% and 0.5% Hyperbaric Bupivacaine


  • Muhammad Salman Maqbool Associate Professor, Department of Anesthesiology & Intensive Care Unit, Rawal General and Dental Hospital, Rawal Institute of Health Sciences, Islamabad




Spinal Anesthesia, Hyperbaric Bupivacaine, Vasopressors


Objective: To appraise clinical effects of 0.5% and 0.75% hyperbaric bupivacaine in general surgical patients undertaking procedure in spinal anesthesia employing crystalloid fluid preload / co-load.

Place and Duration: Islam Teaching Hospital, Islam Medical College, Sialkot and Rawal General and Dental Hospital, Rawal Institute of Health Sciences, Islamabad from 03-4-2012 to 18-9-2012 and from 19-9-2017 to 30-5-2018.

Methodology:  The study consisted of one hundred and twenty-four cases which were divided by lottery into two equal components i.e group-1 and group-2 using 0.5% and 0.75% hyperbaric bupivacaine respectively for intrathecal block in general surgical patients. After spinal block hemodynamic monitoring continued at one-minute interval for fifteen minutes than at 5 minutes interval. Intravascular fluids colloids/crystalloid were given as preload and coload. After the procedure, monitoring continued in post-anesthesia care unit. Statistical analysis was done by SPSS version 19.

Results: In group-1 in two cases (3.22%) and in group-2 in thirteen cases(20.96%) required vasopressors. The mean systolic and diastolic blood pressure(mmHg) in group-1 being 135.70(with SD of 26.37) and 78.70(with SD of 32.5), similar readings in group-2 being 131.78( SD of 26.25) and 79.36(SD of 32.50) respectively. Pearson’s Chi-square test, comparing two quantitative variables i.e. systolic blood pressure readings between both groups was performed p-value came out to be <0.05 and considered statistically significant.

Conclusion: There was no significant statistical hemodynamic difference between the two groups however in 0.5% hyperbaric solution, vasopressor and atropine need was significantly less with more stable hemodynamic profile in the study.






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