Assessment of Thyroid Stimulating Hormones (TSH) Levels In Patients with goiter, A Clinicopathological Study


  • Kamran Masud Assistant Professor of Pathology, FUMC, Islamabad
  • Tariq Butt Professor of Pathology FUMC, Islamabad
  • Ummarah Kamran Medical Officer, Department of Radiology, Rawalpindi Institute of Cardiology, Rawalpindi



Goitre, thyroid function test, Hyperthyroidism, Hypothyroidism


Objective: To determine the blood level of TSH in individuals with goiter being clinically Euthyroid & having a normal blood level of T3 & T4.
Duration & Place of study: January 2015 to June 2015 at PIMS & NORI, Islamabad

Study Design: Descriptive study.
Methodology: One hundred and eighty-two subjects were studied to assess the role of TSH in the development of goiter in the euthyroid goitrous population of Islamabad and Rawalpindi area. The euthyroid goitrous subjects were selected by clinical examination. Radioisotope uptake scan was done to confirm the clinical assessment of the status of the thyroid gland. The estimation of the serum levels of the thyroid hormones and TSH was done by RIA. 
Results: There were 19 (10.4%) males and 163 (89.6%) females between 8 years and 70 years of age. Mean age was 33.76 + 13.77 years. There were 16 individuals who revealed deranged TSH with 8 showing increased & 8 decreased TSH. The mean age in these individuals was 37.63 + 12.52 years. The goiter type was diffuse in 8, Diffuse Nodular (DN) in 3 and multinodular goiter (MNG) in 5 individuals. In patients with normal TSH the goiter type was Diffuse in 72, DN in 60 and MNG in 50 individuals. The means and SD of T3/T4 ratio was 12.86 + 2.38 (p=0.5596) and for TSH serum level in Euthyroid goiter was 1.37 + 1.41 mIU/l.(p=0.6915)
Conclusion: Patients with goiterous enlargement may or may not have normal TSH levels