Respiratory Parameters during Different (Menstrual, Luteal) Phases of the Menstrual Cycle in Healthy Adult Female

Authors

  • Hira Saeed Khan Assistant professor, department of physiology, Suleman Roshan Medical College Tando Adam
  • Saima Naz Shaikh Assistant professor, department of physiology, Liaquat University of Medical and Heath Sciences
  • Rizwan Ali Canna Assistant professor, department of physiology, Suleman Roshan Medical College Tando Adam
  • Kavita Bai Assistant professor of Physiology Indus Medical College, Tando Muhammad Khan

Keywords:

Respiratory function, menstrual phase, luteal phase

Abstract

Objective: To compare the respiratory parameters during different (menstrual, luteal) phases of the menstrual cycle in healthy adult female

Methodology: This comparative study was conducted in research lab physiology department of (LUMHS) Liaquat University of medical and health sciences Jamshoro after approval of Research Ethics Committee of LUMHS. Study duration was 6 months.  All adult healthy non-pregnant females aged between 18 and 24 years were Included. The subjects were notified regarding the purpose and methodology of current research. All the participants were examined regarding the menstrual cycle in two phases (luteal and menstrual). The preliminary clinical, respiratory system examination was performed. Each participant was advised to visit the Physiology Lab on a particular date for pulmonary function test during menstrual (1-5th day) and luteal (19-22nd day) phases of menstrual cycle, based on their menstrual history. Using the Power lab AD tools 15:HT Computerized Spirometer and parameters recorded on Labtutor software, the participants were made to undertake pulmonary function testing in distinct menstrual cycle stages (menstrual and luteal). All the data was collected via study proforma and analysis of data was done by SPSS version 20.

Results: A total of 255 women were studied, their mean age was 20.03+6.30 years and mean BMI was 20.38±1.39. Out of all 10 females were married and 245 females were unmarried and their mean duration of menstrual cycle was 28.62±1.35 days. Mean FVC value was significantly higher in luteal phase as compared to menstrual phase. i.e. Luteal Phase: 2.57 vs. Menstrual Phase: 2.50, (p-0.016).  Average FEV1 value was significantly higher in luteal phase as compared to menstrual phase. i.e. Luteal Phase: 2.61 vs. Menstrual Phase: 2.53, (p-0.009). Although mean PEF value and Mean FEV1/FVC value were also significantly higher in luteal phase as compared to menstrual phase (p-<0.05).

Conclusion: Pulmonary functions as well as respiratory efficiency were significantly improved in the luteal phase as compared to menstrual phase of menstrual cycle, which were enumerated in this study thus suggesting a possible beneficial role of progesterone in improvement of respiratory parameters. The reason could be the bronchodilator effect of progesterone, its level remains higher during this phase. Clinicians treating young female patients suffering from respiratory disorders may keep this in mind about the phases of menstrual cycle while prescribing bronchodilator drugs. Also, conditions like, premenstrual asthma can be better tackled with the help of these observations.

Published

2022-05-06

Issue

Section

Original Articles