Correlation of Chronic Obstructive Pulmonary Disease severity with C-Reative Protien levels in patients at tertiary care Hospital


  • Ghulam Nabi Pathan Assistant Professor of Physiology, Indus Medical College, Tando Muhammad Khan
  • Muhammad Zaman Baloch Assistant Professor of Cardiology, Indus Medical College, Tando Muhammad Khan
  • Yar Muhammad Nizamani Assistant Professor of Physiology, Isra University, Hyderabad
  • Rizwan Channa Senior registrar medicine, BDMC, Mirpurkhas
  • Rizwan Talpur Lecturer, Isra University, Hyderabad



COPD, CRP, Severity score


Objective: To determine the correlation of chronic obstructive pulmonary disease (COPD) severity and C-reactive protein (CRP) among patients at tertiary care Hospital.

Methodology: This cross-sectional study was conducted at Medicine department of Isra University Hospital Hyderabad. All the patients of chronic pulmonary disease either of gender were included. The severity of the disease was assessed as per GOLD standards criteria as mild, moderate, severe and very severe based on spirometry. After taking informed consent, 3 ml blood sample was taken from each patient for C - reactive protein measurement. All the data was recorded in the proforma.

Results:  Total of 101 patients were studied; their mean age was 56.59±13.35 years. Males were in majority 94.06%. 43.6% patients had mild COPD, 25.7% had moderate, 20.7% had severe and 9.9% patients had very severe COPD. There was a significant association between the severity of disease and elevated CRP level, p-value 0.001. A strong positive correlation was found between C - reactive protein level and chronic pulmonary disease, r-value 0.726 and p-value 0.005.

Conclusion: Elevated serum level of CRP is a predictive factor for COPD as an inflammatory biomarker because it increases in chronic obstructive pulmonary disease patients causing a systemic chronic inflammatory process.





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